Pharmaceutical Biotechnology

Pharmaceutical Biotechnology explores the development of protein-based therapeutic substances.• Provides a working knowledge of the preparation, stability, and formulation of protein and peptide drugs•Examines the successful evolution of humanized monoclonal antibodies (MAbs) to treat rheumatoid arthritis and other diseases• Considers the currently disappointing results of genetic engineering and genomics that have isolated disease-responsible genes without significant clinical effect to date• Looks at the market and scientific reasons behind the failure of many biotechnology products to live up to their hype• Discusses regulatory and compendial issues and concludes with a look at future challenges facing biotechnology

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Aerosols Handbook: Measurement, Dosimetry, and Health Effects

As more attention is dedicated to understanding the occupational health risks associated with the industrialmanufacture and use of nanotechnology, Aerosols Handbook: Measurement, Dosimetry, and Health Effects is a timely presentation of the latest research in the field of aerosol science. The book covers a multitude of topics on indoor, outdoor, and industrial aerosols, including aerosol measurement, deposition, particle size distribution, and biokinetic processes. Where harmful exposure to ultrafine particles may occur through inhalation, dermal contact, and ingestion, this book discusses how the size, shape, and chemical properties of particles affect aerosol deposition in the lungs, possibly other organs, and the overall toxicity. The book covers all relevant aspects of aerosols, from epidemiology to molecular biology, and emphasizes the importance of accurate aerosol measurement. The authors discuss Chernobyl accident and miners' lungs in detail to illustrate the effects of radioactive aerosols. The final section focuses on the health effects of specific aerosols, such as diesel aerosols and ultrafine particles. By converging research from both radioactive and non-radioactive aerosols, the editors give the book a unique and more complete perspective of how aerosols behave in the lungs. Aerosols Handbook: Measurement, Dosimetry, and Health Effects is an essential resource for those who study exposure, dosages, and toxicity to develop treatments for exposure, reduce air pollution, and establishbetter safety regulations, particularly in industries using nanotechnologies.

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Medicinal Chemistry

The qualified success and general appeal of Medicinal Chemistry is not only confined to the Indian subcontinent, but it has also won an overwhelming popularity in other parts of the world. Specific care has been taken to maintain and sustain the fundamental philosophy of the textbook embracing rigidly the original pattern and style of presentation with a particular expatiated treatment of synthesis of potential medicinal compounds for the ultimate benefits of the ?teachers and the taught? alike.The present thoroughly revised and skilfully expanded Fourth Edition essentially contains three new and important chapters, namely : Molecular Modeling and Drug Design (Chapter 3), Adrenocortical Steroids (Chapter 24), and Antimycobacterial Agents (Chapter 26) so as to make the textbook more useful to its readers.With the advent of thirty chapters the present updated form of Medicinal Chemistry will prove to be an asset for M.Pharm./B.Pharm. Degree Students, M.Sc. Pharmaceutical Chemistry, M.Sc. Applied Chemistry and M.Sc. Industrial Chemistry throughout the Indian Universities.Medicinal Chemistry appears as a newly designed and artistically presented in a two-colour scheme so as to facilitate a distinctly more effective use of the book.This highly readable, lucid, handy, and exceptionally knowledgeable textbook will definitely win a better, bigger, and confident place for itself amongst its valued readers. 



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Pharmacovigilance, 2nd edition

 The new edition has been completely revised and updated to include the latest theoretical and practical aspects of pharmacovigilance including legal issues, drug regulatoryrequirements, methods of signal generation, reporting schemes and pharmacovigilance in selected system-organ classes. .
The editors and contributors are of excellent standing within the pharmacovigilance community
The text provides exemplary coverage of all the relevant issues
The definitive book on the subject.

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http://rapidshare.com/files/136440644/tpharmacovigilance2ed.zip

Handbook of Pharmaceutical Granulation Technology, Second Edition

Applying basic theories to industrial practices in pharmaceutical development, this Second Edition explainshow new and emerging technologies are utilized in the production of pharmaceutical granulation-demonstrating cost-effective strategies to manufacture solid-dosage forms with consistent physical properties while complying with current regulatory requirements. New chapters cover process modeling, scale-up considerations, rapid release granulation techniques, melt granulation and pelletization, effervescent granulation, rapid release, and process analytical technology. Updated sections cover the theory of granulation from an engineering perspective and the regulatory standards.

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Goodman & Gilman's The Pharmacological Basis of Therapeutics

The undisputed leader in medical pharmacology, without equal. Updated to reflect all critical newdevelopments in drug action and drug-disease interaction. This is the “desert island” book of all medical pharmacology—if you can own just one pharmacology book, this is it.

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http://rapidshare.com/files/148477219/tgg_pharmacol_therapeu.zip

Validation of Pharmaceutical Processes, 3rd Edition

Completely revised and updated to reflect the significant advances in pharmaceutical production and regulatory expectations, this third edition of Validation of Pharmaceutical Processes examines and blueprints every step of the validation process needed to remain compliant and competitive. The many chapters added to the prior compilation examine validation and six sigma system design; the preparation of aseptic and non-aseptic pharmaceutical products; active pharmaceutical ingredient and biotechnology processes, computerized systems; qualification and cleaning of equipment; analytical methods, calibration and certification. As the industry's leading source for validation of sterile pharmaceutical processes for more than 10 years, this greatly expanded is a comprehensive analysis of all of the fundamental elements of this arena with practical solutionsfor every pharmaceutical and bio-pharmaceutical production process. Presenting theoretical knowledge and applied practical considerations, this title · provides an in-depth discussion of recent advances in sterilization · identifies obstacles that may be encountered at any stage of the validation program, and suggests the newest and most advanced solutions · explores distinctive and specific process steps, and identifies critical process control points to reach acceptable results · blends the use of theoretical knowledge with recent technological advancements to achieve applied practical solutions

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Microencapsulation: Methods and Industrial Applications, Second Edition

Presenting breakthrough research pertinent to scientists in a wide range of disciplines-from medicine and biotechnology to cosmetics and pharmacy-this Second Edition provides practical approaches to complex formulation problems encountered in the development of particulate delivery systems at the micro- and nano-size level. Completely revised and expanded to represent the most up-to-date studies in the field, this guide covers advances in pulsatile delivery systems, injectable microparticulate systems, and site-specific delivery systems, as well as potential therapeutic applications of nanotechnology.


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Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs

Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem of major significance, the pharmaceutical industryhas been slow to apply and further develop this technology. This title provides a comprehensive summary of the theoretical and practical aspects of oral lipid-based formulations for use in industry, and provides further insights into a developing technology expected to assume increasing prominence in years to come.

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Handbook of Membrane Separations: Chemical, Pharmaceutical, Food, and Biotechnological Applications

The Handbook of Membrane Separations: Chemical, Pharmaceutical, and Biotechnological Applicationsprovides detailed information on membrane separation technologies as they have evolved over the past decades. To provide a basic understanding of membrane technology, this book documents the developments dealing with these technologies. It explores chemical, pharmaceutical, food processing and biotechnologicalApplications of membrane processes ranging from selective separation to solvent and material recovery. This text also presents in-depth knowledge of membrane separation mechanisms, transport models, membrane permeability computations, membrane types and modules, as well as membrane reactors.


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Handbook of Pharmaceutical Analysis by HPLC, Volume 6

High pressure liquid chromatography frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the essence of major pharmaceutical applications (assays, stability testing, impurity testing, dissolution testing, cleaning validation, high-throughput screening,* A complete reference guide to HPLC* Describes best practices in HPLC and offers 'tricks of the trade' in HPLC operation and method development* Reviews key HPLC pharmaceutical applications and highlights currents trends in HPLC ancillary techniques, samplepreparations, and data handling.


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Modern Practice of Gas Chromatography

The bible of gas chromatography-offering everything the professional and the novice need to know about running, maintaining, and interpreting the results from GC Analytical chemists, technicians, and scientists in allied disciplines have come to regard Modern Practice of Gas Chomatography as the standard reference in gas chromatography. In addition to serving as an invaluable reference for the experienced practitioner, this bestselling work provides the beginner with a solid understanding of gas chromatographic theory and basic techniques.This new Fourth Edition incorporates the most recent developments in the field, including entirely new chapters on gas chromatography/mass spectrometry (GC/MS); optimization of separations and computer assistance; high speed or fast gas chromatography; mobile phase requirements: gas system requirements and sample preparation techniques; qualitative and quantitative analysis by GC; updated information on detectors; validation and QA/QC of chromatographic methods; and useful hints for good gas chromatography.As in previous editions, contributing authors have been chosen for their expertise and active participation in their respective areas. Modern Practice of Gas Chromatography, Fourth Edition presents a well-rounded and comprehensive overview of the current state of this important technology, providing a practical reference that will greatly appeal to both experienced chomatographers and novices.


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Troubleshooting LC Systems: A Comprehensive Approach to Troubleshooting LC Equipment and Separations

This book meets the major advances in instrumentation and technology have made high-performance liquid chromatography (HPLC) a pervasive tool in virtually all areas of chemical and biomedical research today. Despite HPLC's enormous growth, technical problems still bedevil most users at least occasionally.Based on their immensely successfulshort courses, Dolan and Snyder's landmark new book --Troubleshooting LC Systems--now makes available to every practicing chromatographer the authors' wealth of expertise from years of hands-on troubleshooting of real-world LC problems--problems that routinely cause crises and unproductive downtime in nearly every lab.Believing that successful troubleshooting requires an understanding of the basics, Dolan and Snyder open by setting forth all the fundamental principles of LC operation, then move on to a microscopic description of all the elements of LC devices, to lay out their optimal preventive maintenance routines, and ultimately to offer an unprecedentedly thorough treatment of each and every facet of troubleshooting.Displaying a special tutorial mastery--honed to a fineness during their ongoing teaching and consulting activities, and a well-received feature column in LC Magazine--the book's chapters cover: automation and robotics • approaches to troubleshooting • reactions of samples • basic separation techniques • valves, tubing, syringes • band broadening and tailing • preventive maintenance • column packing and flushing • individual LC modules • troubleshooting principles • reagents and buffering • specific problems in separation • ghost and vacancy peaks • quantitation and calibration • pumps, seals, and pistons • gradient elution problems • column composition • concentration and blockages • sample cleanup • temperature and mixing effects • detectors and recorders • column packing and flushing.In short, Dolan and Snyder's eminently practical new guide to Troubleshooting LC Systems is an essential laboratory handbook--one that empowers expert and novice chromatographer alike to solve every sort of practical laboratory problem on a day-to-day basis. No one using an LC system should be without it.


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Cosmetic Formulation of Skincare Products

This book covers to meet the needs of the cosmetic chemist and engineer, this reference outlines the latest technologies and issues pertinent to the development novel skin care products including advances in formulation and development, raw materials and active ingredients, compound testing, and clinical assessment. Organized by product category, then by body application area, this guide supplies all one needs to know to create effective skin care products for men and women in a diverse range of ethnic populations.


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